GCC2

Across TCGA cell cohorts, GCC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,846 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCC2-associated GO terms across cancer lineages are Establishment of protein localization to vacuole, Vacuolar transport, and Protein localization to vacuole. Each is linked with GCC2 in more than 18 cancer types. Because this analysis shows association rather than direction, both GCC2-to-partner and partner-to-GCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to vacuole grouped by GCC2-low versus GCC2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCC2→partner) and Y-score (partner→GCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Establishment of protein localization to vacuole →	+0.083	+0.944	.001	.002	3	19
OESOPHAGUS	Vacuolar transport →	+0.067	+0.911	<.001	.002	3	18
URINARY_TRACT	Protein localization to vacuole →	+0.087	+1.225	<.001	.001	3	18
OESOPHAGUS	Lysosomal transport →	+0.072	+1.119	<.001	<.001	3	18
SKIN	Cytosolic transport →	+0.067	+0.915	<.001	<.001	3	18
OVARY	Protein localization to lysosome →	+0.102	+1.017	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,846 associations by consensus.

Establishment of protein localization to vacuole by GCC2 expression — OESOPHAGUS

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