GCC2

Across TCGA cell cohorts, GCC2 mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCC2-associated genes across cancer lineages are GAGE10, DEFB126, and OR52A5. Each is linked with GCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCC2-to-partner and partner-to-GCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE10 grouped by GCC2-low versus GCC2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCC2→partner) and Y-score (partner→GCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GAGE10 →	+0.124	+3.906	.001	.009	3	2
BLOOD_Lymphoma	DEFB126 →	+0.251	+3.714	.001	.006	3	2
BLOOD_Lymphoma	OR52A5 →	+0.349	+4.765	<.001	<.001	3	2
BLOOD_Lymphoma	OR52A1 →	+0.302	+4.459	<.001	.001	3	2
BLOOD_Lymphoma	SULT1C3 →	+0.012	+4.662	<.001	.003	3	2
BLOOD_Lymphoma	OR10D3 →	+0.018	+4.058	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

GAGE10 by GCC2 expression — BLOOD_Myeloma

Explore this box plot interactively →