GCC1

Across TCGA cell cohorts, GCC1 mutation is significantly associated with the RNA expression of many other genes, with 531 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCC1-associated genes across cancer lineages are MCAT, TNRC6B, and POLR3H. Each is linked with GCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GCC1-to-partner and partner-to-GCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCAT grouped by GCC1-low versus GCC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCC1→partner) and Y-score (partner→GCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCAT →	+0.703	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TNRC6B →	+1.043	+3.364	<.001	.002	3	1
LARGE_INTESTINE	POLR3H →	+0.917	+3.364	<.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.812	+3.451	<.001	.002	3	1
LARGE_INTESTINE	FZD3 →	+0.902	+3.364	<.001	.002	3	1
LARGE_INTESTINE	HFE →	+0.840	+3.364	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

MCAT by GCC1 expression — LARGE_INTESTINE

Explore this box plot interactively →