GCC1

Across TCGA pan-cancer cohorts, GCC1 RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated GCC1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GCC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GCC1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

CESC, KIRC, and KIRP are the cancer types where GCC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.669	0.819	.001	78	view →
KIRC	DFS	Median	All	0.709	0.539	<.001	67	view →
KIRP	OS	Median	II,III,IV	0.459	0.932	.002	49	view →
LGG	OS	Median	All	0.752	0.868	<.001	37	view →
ACC	OS	Quartile	III,IV	0.888	0.249	.006	35	view →
KICH	DFS	Median	II,III,IV	0.580	0.918	.005	34	view →
MESO	DFS	Median	III,IV	0.236	0.604	.005	27	view →
CHOL	DFS	Median	II,III,IV	0.115	0.630	<.001	21	view →
HNSC	DFS	Tertile	All	0.742	0.626	.010	19	view →
STAD	OS	Tertile	III,IV	0.572	0.314	.022	15	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	15	view →
ESCA	DFS	Tertile	IV	0.704	0.231	.024	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

GCC1–CESC (DFS)

Open the CESC breakdown →