GCAT

Across TCGA patient cohorts, GCAT mutation is significantly associated with the RNA expression of many other genes, with 1,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCAT-associated genes across cancer lineages are HPRT1P3, MIR6779, and EEF1A1P39. Each is linked with GCAT in more than 2 cancer types. Because this analysis shows association rather than direction, both GCAT-to-partner and partner-to-GCAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPRT1P3 grouped by GCAT-low versus GCAT-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCAT→partner) and Y-score (partner→GCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	HPRT1P3 →	+0.207	+5.039	<.001	.008	3	3
CESC	MIR6779 →	+0.863	+4.409	<.001	.006	3	2
SKCM	EEF1A1P39 →	+0.173	+3.885	<.001	.002	3	2
COAD	LINC01707 →	+0.160	+4.693	<.001	<.001	3	2
READ	RBM17P3 →	+0.078	+6.257	<.001	.001	3	2
UCEC	H3P46 →	+0.106	+3.877	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,446 associations by consensus.

HPRT1P3 by GCAT expression — READ

Explore this box plot interactively →