GC

Across TCGA pan-cancer cohorts, GC mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GC data layer compared with 17 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GC expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

COAD, LUAD, and UCEC are the cancer types where GC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.817	1.000	.014	66	view →
LUAD	OS	Quartile	III,IV	0.304	1.000	.006	19	view →
UCEC	DFS	Tertile	II,III,IV	0.631	1.000	.039	12	view →
CCRCC	DFS	Median	II,III,IV	0.295	0.827	.010	11	view →
HNSC	OS	Median	All	0.956	1.000	.014	5	view →
PDAC	OS	Tertile	III,IV	0.328	0.932	.031	5	view →
LSCC	DFS	Tertile	II,III,IV	0.842	1.000	.019	5	view →
GBM	OS	Tertile	All	0.883	0.745	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GC–COAD (DFS)

Open the COAD breakdown →