GBX1

Across TCGA patient cohorts, GBX1 mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBX1-associated genes across cancer lineages are IGHV2-70, RPS29P32, and MIR6784. Each is linked with GBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBX1-to-partner and partner-to-GBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHV2-70 grouped by GBX1-low versus GBX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBX1→partner) and Y-score (partner→GBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV2-70 →	+2.419	+3.467	<.001	.002	3	1
UCEC	RPS29P32 →	+0.563	+2.921	<.001	.001	3	1
UCEC	MIR6784 →	+0.808	+2.415	.004	.003	3	1
HNSC	MIR449B →	+0.323	+7.954	<.001	.008	3	1
UCEC	CPAMD8 →	-1.248	-3.563	.006	.003	3	1
UCEC	KIF6 →	-0.483	-3.574	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

IGHV2-70 by GBX1 expression — UCEC

Explore this box plot interactively →