Across TCGA cell cohorts, GBP7 mutation is significantly associated with the RNA expression of many other genes, with 290 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBP7-associated genes across cancer lineages are MAGEB4, C12orf40, and PRAMEF10. Each is linked with GBP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP7-to-partner and partner-to-GBP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP7→partner) and Y-score (partner→GBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	2
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF15 →	+0.478	+4.817	<.001	.001	3	1
LUNG_SCLC	OR5H8 →	+0.017	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 290 associations by consensus.

Exploration

GBP7 survival (RNA) · tumor vs normal (RNA) · all GBP7 data types