GBP4

Across TCGA patient cohorts, GBP4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP4-associated genes across cancer lineages are 14-3-3_beta, GAPDH, and P-Cadherin. Each is linked with GBP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GBP4-to-partner and partner-to-GBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GBP4-low versus GBP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP4→partner) and Y-score (partner→GBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.099	-3.143	.017	.018	3	2
UCEC	GAPDH →	+0.464	+2.999	.036	.035	3	2
UCEC	P-Cadherin →	-0.159	-2.308	.007	.006	3	2
UCEC	PCNA →	+0.226	+2.321	.011	.006	3	2
UCEC	Annexin_VII →	-0.137	-2.321	.016	.006	3	2
UCEC	ATM →	-0.560	-1.807	.002	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by GBP4 expression — UCEC

Explore this box plot interactively →