GBP4

Across TCGA cell cohorts, GBP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,070 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GBP4-associated GO terms across cancer lineages are CD8-positive, alpha-beta T cell homeostasis, CD8-positive, alpha-beta T cell activation, and Negative regulation of regulatory T cell differentiation. Each is linked with GBP4 in more than 16 cancer types. Because this analysis shows association rather than direction, both GBP4-to-partner and partner-to-GBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8-positive, alpha-beta T cell homeostasis grouped by GBP4-low versus GBP4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP4→partner) and Y-score (partner→GBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD8-positive, alpha-beta T cell homeostasis →	+0.189	+2.255	.001	.006	3	17
BREAST	CD8-positive, alpha-beta T cell activation →	+0.160	+1.381	<.001	<.001	3	17
URINARY_TRACT	Negative regulation of regulatory T cell differentiation →	+0.245	+2.742	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	T-helper 17 type immune response →	+0.151	+2.556	<.001	<.001	3	15
PANCREAS	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.246	+2.216	<.001	<.001	3	15
OESOPHAGUS	Cytolysis in another organism →	+1.397	+0.785	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,070 associations by consensus.

CD8-positive, alpha-beta T cell homeostasis by GBP4 expression — URINARY_TRACT

Explore this box plot interactively →