GBP2

Across TCGA patient cohorts, GBP2 mutation is significantly associated with the RNA expression of many other genes, with 2,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBP2-associated genes across cancer lineages are COX6B1P6, HNRNPCP1, and RNY4P14. Each is linked with GBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP2-to-partner and partner-to-GBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6B1P6 grouped by GBP2-low versus GBP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP2→partner) and Y-score (partner→GBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COX6B1P6 →	+0.049	+2.771	<.001	.003	3	2
SKCM	HNRNPCP1 →	+0.480	+3.478	.005	.002	3	2
CESC	RNY4P14 →	+0.332	+5.144	<.001	.003	3	2
SKCM	ITGB1BP1 →	+0.439	+2.031	.002	.005	3	2
UCEC	TRAJ52 →	+0.405	+1.501	.001	.009	3	2
CESC	FAM96AP1 →	+0.089	+6.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,578 associations by consensus.

COX6B1P6 by GBP2 expression — SKCM

Explore this box plot interactively →