GBP1

Across TCGA cell cohorts, GBP1 mutation is significantly associated with the RNA expression of many other genes, with 173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBP1-associated genes across cancer lineages are PRB1, PPIAL4D, and HMGXB4. Each is linked with GBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP1-to-partner and partner-to-GBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRB1 grouped by GBP1-low versus GBP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP1→partner) and Y-score (partner→GBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRB1 →	+0.366	+3.321	<.001	.006	3	1
CNS	PPIAL4D →	+0.120	+3.602	<.001	.006	3	1
LARGE_INTESTINE	HMGXB4 →	+0.708	+3.237	<.001	.003	3	1
LARGE_INTESTINE	NUMBL →	+0.996	+3.212	.001	.006	3	1
LARGE_INTESTINE	TWIST1 →	+1.460	+3.371	<.001	.004	3	1
LARGE_INTESTINE	FXR2 →	+0.630	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 173 associations by consensus.

PRB1 by GBP1 expression — CNS

Explore this box plot interactively →