GBA3

Across TCGA patient cohorts, GBA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,168 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GBA3-associated proteins across cancer lineages are DENND5B_S1076, ARHGEF37_S251, and COBL_S917. Each is linked with GBA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBA3-to-partner and partner-to-GBA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GBA3 versus DENND5B_S1076 in LSCC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA3→partner) and Y-score (partner→GBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DENND5B_S1076 →	+0.821	+0.525	<.001	.001	3	4
UCEC	ARHGEF37_S251 →	+1.093	+1.150	<.001	<.001	3	4
CCRCC	COBL_S917 →	+0.926	+2.415	.004	.001	3	3
CCRCC	HDDC3 →	+0.409	+2.167	<.001	<.001	3	3
HNSC	HID1 →	+0.512	+0.448	.001	.008	3	3
LUAD	PLCL2_S1113 →	+0.761	+0.369	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,168 associations by consensus.

GBA3 vs DENND5B_S1076 — LSCC

Explore this scatter interactively →