GBA3

Across TCGA patient cohorts, GBA3 mutation is significantly associated with the RNA expression of many other genes, with 2,765 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBA3-associated genes across cancer lineages are BRIX1, MYPOP, and FCER1A. Each is linked with GBA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBA3-to-partner and partner-to-GBA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRIX1 grouped by GBA3-low versus GBA3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA3→partner) and Y-score (partner→GBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BRIX1 →	+0.645	+2.269	<.001	.005	3	3
LUAD	MYPOP →	+0.404	+4.035	.001	<.001	3	3
UCEC	FCER1A →	-0.750	-3.063	.001	<.001	3	3
UCEC	NAP1L4 →	+0.339	+2.962	.001	<.001	3	3
UCEC	PDCD2L →	+0.354	+1.968	.009	.002	3	3
UCEC	AUNIP →	+0.719	+2.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,765 associations by consensus.

BRIX1 by GBA3 expression — LUAD

Explore this box plot interactively →