GBA3

Across TCGA patient cohorts, GBA3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GBA3-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and p90 RSK_pT359_S363. Each is linked with GBA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GBA3-to-partner and partner-to-GBA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GBA3-low versus GBA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA3→partner) and Y-score (partner→GBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.765	+1.505	.001	.034	3	4
LUAD	MSH2 →	+0.343	+2.186	.012	.034	3	2
UCEC	p90 RSK_pT359_S363 →	-0.201	-2.000	.011	.029	3	2
UCEC	PCNA →	+0.292	+3.169	<.001	<.001	3	2
UCEC	AMPK_alpha →	-0.167	-2.000	.025	.010	3	2
UCEC	STAT3_pY705 →	-0.432	-2.222	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by GBA3 expression — UCEC

Explore this box plot interactively →