GBA3

Across TCGA cell cohorts, GBA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 345 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GBA3-associated GO terms across cancer lineages are Intestinal epithelial cell development, Glycosylceramide catabolic process, and Regulation of mRNA catabolic process. Each is linked with GBA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GBA3-to-partner and partner-to-GBA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intestinal epithelial cell development grouped by GBA3-low versus GBA3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA3→partner) and Y-score (partner→GBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Intestinal epithelial cell development →	+0.538	+0.229	.003	.006	3	3
LUNG_SCLC	Glycosylceramide catabolic process →	-0.203	-1.112	<.001	.003	3	3
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.035	+0.055	.006	.009	2	3
SOFT_TISSUE	Oligosaccharide catabolic process →	-0.113	-0.058	<.001	.008	2	3
OVARY	Regulation of ERBB signaling pathway →	-0.034	-0.066	.004	.002	3	2
OVARY	Carbon catabolite regulation of transcription →	+0.072	+0.075	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

Intestinal epithelial cell development by GBA3 expression — BLOOD_Leukemia

Explore this box plot interactively →