GBA

Across TCGA patient cohorts, GBA RNA expression is significantly associated with the protein abundance of many other proteins, with 11,125 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GBA-associated proteins across cancer lineages are SCAMP3, TRMT1L, and TPMT. Each is linked with GBA in more than 4 cancer types. Because this analysis shows association rather than direction, both GBA-to-partner and partner-to-GBA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GBA versus SCAMP3 in PDAC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA→partner) and Y-score (partner→GBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCAMP3 →	+0.367	+0.341	.001	<.001	3	5
LSCC	TRMT1L →	+0.303	+0.321	.009	.002	3	5
GBM	TPMT →	+0.315	+0.426	<.001	<.001	3	4
GBM	HS1BP3 →	+0.281	+0.434	<.001	<.001	3	4
UCEC	ADAR →	+0.251	+0.811	<.001	<.001	2	5
PDAC	CERS2 →	+0.484	+0.303	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,125 associations by consensus.

GBA vs SCAMP3 — PDAC

Explore this scatter interactively →