GATC

Across TCGA pan-cancer cohorts, GATC RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GATC data layer compared with 4 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GATC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GATC expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

LIHC, MESO, and LGG are the cancer types where GATC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.602	0.771	<.001	122	view →
MESO	OS	Median	All	0.266	0.495	<.001	120	view →
LGG	OS	Median	All	0.348	0.543	<.001	51	view →
UVM	DFS	Tertile	III,IV	0.215	0.844	.003	50	view →
KIRC	DFS	Tertile	All	0.827	0.489	<.001	38	view →
SCLC	OS	Quartile	II,III,IV	0.708	0.168	.003	36	view →
HNSC	OS	Tertile	All	0.161	0.569	<.001	32	view →
BRCA	DFS	Tertile	III,IV	0.943	0.815	.001	30	view →
PAAD	DFS	Quartile	II,III,IV	0.321	0.565	.017	25	view →
BLCA	DFS	Quartile	All	0.275	0.576	.005	25	view →
ACC	OS	Quartile	All	0.783	0.970	.004	19	view →
UCEC	DFS	Tertile	All	0.795	0.902	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GATC–LIHC (OS)

Open the LIHC breakdown →