GATC

Across TCGA pan-cancer cohorts, GATC RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of GATC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GATC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GATC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where GATC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.915	<.001	12	view →
BLCA	All	III,IV	+0.747	<.001	11	view →
LIHC	Male	II,III,IV	+0.808	<.001	9	view →
STAD	Male	II,III,IV	+0.980	<.001	8	view →
COAD	Female	II,III,IV	+0.765	<.001	8	view →
THCA	Male	All	−0.381	<.001	8	view →
UCEC	All	III,IV	+0.829	<.001	6	view →
LUSC	Male	II,III,IV	+0.654	<.001	6	view →
BRCA	All	II,III,IV	+0.246	<.001	6	view →
CHOL	Male	All	+1.223	<.001	4	view →
LUAD	Male	II,III,IV	+0.623	<.001	4	view →
KICH	All	All	−0.584	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

GATC–HNSC

Open the HNSC breakdown →