GATB

Across TCGA pan-cancer cohorts, GATB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of GATB’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GATB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GATB is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where GATB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.560	<.001	12	view →
PDAC	All	All	−0.524	<.001	6	view →
LSCC	Male	II,III,IV	+0.161	<.001	5	view →
COAD	Female	All	−0.099	.023	4	view →
HNSC	All	All	−0.083	.022	2	view →
LUAD	Female	III,IV	−0.280	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

GATB–CCRCC

Open the CCRCC breakdown →