GATB

Across TCGA patient cohorts, GATB mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATB-associated genes across cancer lineages are p27_pT198, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with GATB in more than 1 cancer types. Because this analysis shows association rather than direction, both GATB-to-partner and partner-to-GATB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by GATB-low versus GATB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATB→partner) and Y-score (partner→GATB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.107	+2.807	.005	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.619	+2.135	.003	.010	3	2
UCEC	14-3-3_beta →	-0.074	-2.673	.040	.005	3	1
UCEC	eIF4E →	+0.162	+2.584	.032	.010	3	1
UCEC	Fibronectin →	-0.293	-2.405	.013	.003	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.418	+1.925	.022	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

p27_pT198 by GATB expression — UCEC

Explore this box plot interactively →