GATA6-AS1

Across TCGA pan-cancer cohorts, GATA6-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GATA6-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GATA6-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GATA6-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

KIRC, UVM, and LUSC are the cancer types where GATA6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.536	0.696	<.001	100	view →
UVM	DFS	Tertile	All	0.502	0.829	<.001	97	view →
LUSC	DFS	Median	II,III,IV	0.276	0.493	.001	67	view →
KIRP	DFS	Median	II,III,IV	0.432	0.948	<.001	54	view →
PAAD	OS	Median	All	0.591	0.394	<.001	39	view →
LGG	DFS	Tertile	All	0.312	0.466	<.001	28	view →
ACC	DFS	Tertile	All	0.277	0.661	.006	28	view →
PRAD	DFS	Tertile	All	0.716	0.908	<.001	26	view →
TGCT	DFS	Median	All	0.552	0.790	.002	12	view →
OV	DFS	Quartile	II,III,IV	0.118	0.216	.039	12	view →
ESCA	OS	Quartile	All	0.401	1.000	.015	12	view →
READ	OS	Quartile	II,III,IV	1.000	0.825	.030	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GATA6-AS1–KIRC (DFS)

Open the KIRC breakdown →