GATA6-AS1

Across TCGA pan-cancer cohorts, GATA6-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GATA6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GATA6-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GATA6-AS1 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and LUAD are the cancer types where GATA6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATA6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.175	<.001	11	view →
KIRC	All	II,III,IV	−0.238	<.001	11	view →
LUAD	Female	III,IV	−2.168	<.001	9	view →
LUSC	Female	All	−2.188	<.001	8	view →
UCEC	All	II,III,IV	−2.903	<.001	6	view →
KICH	All	III,IV	−0.940	<.001	6	view →
BRCA	All	III,IV	−0.483	<.001	6	view →
KIRP	All	All	−0.289	<.001	6	view →
STAD	All	IV	−3.216	.001	2	view →
CHOL	All	All	+1.424	.002	2	view →
PRAD	All	All	−0.218	.001	2	view →
READ	Female	All	+0.744	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GATA6-AS1–BLCA

Open the BLCA breakdown →