GATA5

Across TCGA patient cohorts, GATA5 mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA5-associated genes across cancer lineages are RNU6ATAC30P, RPL32P19, and TMEM269. Each is linked with GATA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA5-to-partner and partner-to-GATA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC30P grouped by GATA5-low versus GATA5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA5→partner) and Y-score (partner→GATA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6ATAC30P →	+0.292	+4.328	<.001	<.001	3	2
COAD	RPL32P19 →	+0.212	+4.017	<.001	.003	3	2
UCEC	TMEM269 →	+0.215	+3.324	<.001	.007	3	1
UCEC	MIR6766 →	+0.248	+2.773	<.001	.004	3	1
UCEC	IGKV1D-13 →	+2.529	+3.906	<.001	<.001	3	1
UCEC	MIR8071-2 →	+0.960	+2.712	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

RNU6ATAC30P by GATA5 expression — SKCM

Explore this box plot interactively →