GATA5

Across TCGA pan-cancer cohorts, GATA5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GATA5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GATA5 RNA is repressed in tumor relative to normal tissue. In most cancer types GATA5 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where GATA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.816	<.001	12	view →
BLCA	Male	IV	−4.529	<.001	11	view →
KICH	Female	All	−1.676	<.001	10	view →
KIRP	Male	All	−1.461	<.001	9	view →
LUAD	All	III,IV	−1.063	<.001	9	view →
BRCA	Female	II,III,IV	+0.637	<.001	8	view →
STAD	All	IV	−2.816	.006	6	view →
UCEC	All	All	−2.378	<.001	6	view →
LUSC	Female	II,III,IV	−1.652	<.001	6	view →
PRAD	All	All	−1.247	<.001	2	view →
THCA	Male	III,IV	−0.912	.014	2	view →
ESCA	All	All	−1.650	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GATA5–KIRC

Open the KIRC breakdown →