GATA4

Across TCGA pan-cancer cohorts, GATA4 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of GATA4’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where GATA4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GATA4 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC are the cancer types where GATA4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATA4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−1.482	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

GATA4–PDAC

Open the PDAC breakdown →