GATA4

Across TCGA pan-cancer cohorts, GATA4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GATA4 data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GATA4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GATA4 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

KIRP, UVM, and ACC are the cancer types where GATA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.544	0.774	<.001	129	view →
UVM	OS	Median	All	0.944	0.446	<.001	126	view →
ACC	OS	Median	All	0.395	0.831	<.001	114	view →
KIRC	OS	Tertile	II,III,IV	0.379	0.624	<.001	70	view →
LGG	DFS	Median	All	0.626	0.828	<.001	54	view →
UCEC	OS	Quartile	All	0.878	0.946	.001	28	view →
HNSC	DFS	Tertile	IV	0.533	0.300	.003	24	view →
SKCM	OS	Median	II,III,IV	0.776	0.900	.004	21	view →
ESCA	OS	Median	All	0.647	1.000	.015	19	view →
COAD	OS	Tertile	All	0.804	0.912	.015	18	view →
LIHC	OS	Quartile	III,IV	0.348	0.849	.007	16	view →
THYM	DFS	Quartile	All	0.693	0.904	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GATA4–KIRP (OS)

Open the KIRP breakdown →