GATA4

Across TCGA patient cohorts, GATA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,982 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible GATA4-associated GO terms across cancer lineages are Positive regulation of chromosome organization, DNA synthesis involved in DNA repair, and Regulation of chromosome organization. Each is linked with GATA4 in more than 12 cancer types. Because this analysis shows association rather than direction, both GATA4-to-partner and partner-to-GATA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome organization grouped by GATA4-low versus GATA4-high in LIHC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA4→partner) and Y-score (partner→GATA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Positive regulation of chromosome organization →	+0.033	+0.908	<.001	<.001	3	13
LIHC	DNA synthesis involved in DNA repair →	+0.035	+0.822	<.001	<.001	3	13
LIHC	Regulation of chromosome organization →	+0.037	+0.914	<.001	<.001	3	13
LIHC	Negative regulation of chromosome organization →	+0.042	+0.800	<.001	<.001	3	12
KIRC	Regulation of protein serine/threonine kinase activity →	+0.024	+0.225	<.001	<.001	3	12
ACC	Cytoskeleton-dependent cytokinesis →	+0.042	+2.245	.002	<.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,982 associations by consensus.

Positive regulation of chromosome organization by GATA4 expression — LIHC

Explore this box plot interactively →