GATA4

Across TCGA patient cohorts, GATA4 mutation is significantly associated with the RNA expression of many other genes, with 2,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA4-associated genes across cancer lineages are LIN7C, SRFBP1, and RMND1. Each is linked with GATA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA4-to-partner and partner-to-GATA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by GATA4-low versus GATA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA4→partner) and Y-score (partner→GATA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.698	+3.850	<.001	<.001	3	2
UCEC	SRFBP1 →	+0.571	+2.425	.005	.002	3	2
UCEC	RMND1 →	+0.567	+2.627	.001	.005	3	2
UCEC	LSM12 →	+0.751	+3.807	<.001	<.001	3	2
UCEC	PAQR3 →	+0.471	+2.479	.004	.001	3	2
UCEC	GRPEL2 →	+0.586	+3.716	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,040 associations by consensus.

LIN7C by GATA4 expression — UCEC

Explore this box plot interactively →