GATA4

Across TCGA patient cohorts, GATA4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA4-associated genes across cancer lineages are VHL, c-Met_pY1235, and Cyclin-E2. Each is linked with GATA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA4-to-partner and partner-to-GATA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GATA4-low versus GATA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA4→partner) and Y-score (partner→GATA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.733	-2.115	.013	.019	3	2
UCEC	c-Met_pY1235 →	+0.090	+2.807	.005	.003	3	2
UCEC	Cyclin-E2 →	+0.197	+2.807	.007	.003	3	2
UCEC	A-Raf_pS299 →	-0.141	-3.459	.006	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.166	-3.459	.002	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.442	+1.884	.046	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

VHL by GATA4 expression — UCEC

Explore this box plot interactively →