GATA4

Across TCGA cell cohorts, GATA4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GATA4-associated genes across cancer lineages are OR2T8, TAS2R41, and KRTAP21-1. Each is linked with GATA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA4-to-partner and partner-to-GATA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by GATA4-low versus GATA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA4→partner) and Y-score (partner→GATA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.175	+3.693	<.001	.005	3	1
LARGE_INTESTINE	TAS2R41 →	+0.040	+3.345	<.001	.007	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	DDI1 →	+0.054	+4.087	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR2T8 by GATA4 expression — LARGE_INTESTINE

Explore this box plot interactively →