GATA3

Across TCGA patient cohorts, GATA3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA3-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK2, and PCNA. Each is linked with GATA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GATA3-to-partner and partner-to-GATA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GATA3-low versus GATA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA3→partner) and Y-score (partner→GATA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.496	+1.341	.014	.043	3	3
UCEC	JNK2 →	+0.160	+1.514	.017	.015	3	2
UCEC	PCNA →	+0.229	+2.584	.001	.010	3	2
UCEC	eEF2 →	+0.359	+2.584	.003	.010	3	1
UCEC	EGFR_pY1068 →	-0.292	-2.807	<.001	.002	3	1
UCEC	eIF4E →	+0.155	+3.183	.031	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by GATA3 expression — UCEC

Explore this box plot interactively →