GATA3

Across TCGA pan-cancer cohorts, GATA3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GATA3 data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GATA3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GATA3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

ACC, KIRP, and MESO are the cancer types where GATA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.260	0.636	<.001	114	view →
KIRP	OS	Tertile	II,III,IV	0.337	0.757	<.001	86	view →
MESO	DFS	Quartile	All	0.234	0.450	.006	80	view →
UVM	DFS	Median	All	0.431	0.740	<.001	80	view →
HNSC	DFS	Quartile	All	0.757	0.607	<.001	72	view →
SKCM	OS	Tertile	All	0.427	0.264	.001	64	view →
BLCA	DFS	Quartile	All	0.700	0.535	.001	62	view →
BRCA	DFS	Quartile	III,IV	0.943	0.758	<.001	53	view →
LGG	DFS	Median	All	0.634	0.838	<.001	52	view →
ESCA	DFS	Quartile	III,IV	0.701	0.255	<.001	45	view →
LUAD	DFS	Median	II,III,IV	0.673	0.462	.006	25	view →
LIHC	DFS	Median	II,III,IV	0.501	0.344	.008	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GATA3–ACC (DFS)

Open the ACC breakdown →