GATA3

Across TCGA cell cohorts, GATA3 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GATA3-associated genes across cancer lineages are OR11H1, OR10H2, and SPDYE4. Each is linked with GATA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA3-to-partner and partner-to-GATA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by GATA3-low versus GATA3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA3→partner) and Y-score (partner→GATA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR11H1 →	+0.027	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10H2 →	+0.030	+4.371	.002	.005	3	1
LUNG_NSCLC_LUAD	SPDYE4 →	+0.037	+4.544	.003	.003	3	1
LUNG_NSCLC_LUAD	SHISA6 →	+0.545	+4.212	<.001	.007	3	1
LARGE_INTESTINE	TNRC6B →	+1.094	+3.064	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

OR11H1 by GATA3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →