GATA1

Across TCGA pan-cancer cohorts, GATA1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GATA1 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GATA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GATA1 expression acts as an unfavorable survival marker.

HNSC, OV, and LGG are the cancer types where GATA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.087	0.746	<.001	24	view →
OV	OS	Median	All	0.361	0.842	.004	18	view →
LGG	OS	Median	All	0.182	0.909	<.001	12	view →
SKCM	DFS	Median	All	0.464	0.740	.010	11	view →
LUSC	DFS	Median	II,III,IV	0.139	0.663	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	DFS	Median	All	0.134	0.625	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GATA1–HNSC (OS)

Open the HNSC breakdown →