GAS6-DT

Across TCGA pan-cancer cohorts, GAS6-DT RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GAS6-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAS6-DT RNA is repressed in tumor relative to normal tissue. In most cancer types GAS6-DT is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where GAS6-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAS6-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.583	<.001	11	view →
HNSC	All	III,IV	+1.076	<.001	10	view →
LUAD	Female	All	−0.849	<.001	9	view →
BLCA	Male	IV	−3.275	<.001	8	view →
KIRP	Male	All	−1.378	<.001	7	view →
LUSC	Male	III,IV	−1.299	<.001	7	view →
UCEC	All	III,IV	−2.429	<.001	6	view →
LIHC	All	All	+0.382	<.001	5	view →
CHOL	All	II,III,IV	+1.230	.001	4	view →
BRCA	All	All	−0.397	<.001	4	view →
PRAD	All	All	−0.821	<.001	2	view →
KICH	Male	II,III,IV	+0.925	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GAS6-DT–KIRC

Open the KIRC breakdown →