GAS6-AS1

Across TCGA pan-cancer cohorts, GAS6-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GAS6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAS6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAS6-AS1 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where GAS6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAS6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.512	<.001	12	view →
COAD	All	IV	+2.732	<.001	11	view →
KIRP	Female	All	+2.073	<.001	11	view →
THCA	All	II,III,IV	+0.549	<.001	7	view →
HNSC	Female	II,III,IV	+0.760	.020	6	view →
BRCA	All	III,IV	−0.386	.006	6	view →
UCEC	All	All	−0.704	.006	4	view →
READ	All	All	+2.481	<.001	2	view →
LUSC	Male	II,III,IV	−0.507	.034	2	view →
STAD	Male	II,III,IV	+0.501	.027	2	view →
PRAD	All	All	+0.328	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GAS6-AS1–KIRC

Open the KIRC breakdown →