GAS5-AS1

Across TCGA pan-cancer cohorts, GAS5-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GAS5-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GAS5-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GAS5-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, LGG, and UVM are the cancer types where GAS5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.858	0.442	.001	75	view →
LGG	DFS	Median	All	0.651	0.822	<.001	53	view →
UVM	DFS	Quartile	All	0.417	0.944	.005	47	view →
KIRC	OS	Tertile	All	0.722	0.522	<.001	37	view →
CESC	OS	Median	All	0.863	0.729	.001	24	view →
MESO	OS	Quartile	All	0.518	0.271	.015	20	view →
LIHC	OS	Median	All	0.718	0.838	.007	19	view →
READ	DFS	Tertile	IV	0.337	0.852	.006	16	view →
HNSC	DFS	Tertile	III,IV	0.370	0.694	.004	14	view →
LUSC	DFS	Quartile	III,IV	0.110	0.857	.003	14	view →
CHOL	DFS	Tertile	II,III,IV	0.196	0.607	.006	13	view →
ACC	DFS	Quartile	All	0.214	0.769	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GAS5-AS1–KIRP (DFS)

Open the KIRP breakdown →