GAS5-AS1

Across TCGA pan-cancer cohorts, GAS5-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GAS5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GAS5-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GAS5-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where GAS5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAS5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.877	<.001	10	view →
THCA	Male	III,IV	−0.784	<.001	10	view →
COAD	Female	All	−0.723	<.001	9	view →
LIHC	Male	All	+0.820	<.001	8	view →
LUSC	Male	II,III,IV	−0.531	<.001	6	view →
CHOL	Male	All	+1.438	<.001	4	view →
STAD	All	II,III,IV	+0.419	.014	4	view →
LUAD	Female	II,III,IV	−0.470	.003	3	view →
KIRP	All	III,IV	−0.289	.029	3	view →
UCEC	All	IV	−0.815	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GAS5-AS1–KICH

Open the KICH breakdown →