Across TCGA patient cohorts, GARS1-DT mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GARS1-DT-associated genes across cancer lineages are DNAJA1P4, RNU6ATAC31P, and ATP6V1G1P3. Each is linked with GARS1-DT in more than 1 cancer types. Because this analysis shows association rather than direction, both GARS1-DT-to-partner and partner-to-GARS1-DT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GARS1-DT→partner) and Y-score (partner→GARS1-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJA1P4 →	+0.106	+5.420	<.001	.005	3	1
UCEC	RNU6ATAC31P →	+0.502	+5.081	.004	.008	3	1
UCEC	ATP6V1G1P3 →	+0.274	+5.031	<.001	.009	3	1
UCEC	NUP210P2 →	+0.281	+5.937	<.001	.002	3	1
UCEC	M6PRP1 →	+0.147	+5.358	<.001	.006	3	1
UCEC	RN7SL714P →	+0.270	+5.852	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

GARS1-DT survival (RNA) · tumor vs normal (RNA) · all GARS1-DT data types