GAPT

Across TCGA patient cohorts, GAPT mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAPT-associated genes across cancer lineages are c-Met_pY1235, eIF4E, and eIF4G. Each is linked with GAPT in more than 1 cancer types. Because this analysis shows association rather than direction, both GAPT-to-partner and partner-to-GAPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by GAPT-low versus GAPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAPT→partner) and Y-score (partner→GAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.094	+2.331	<.001	.003	3	2
UCEC	eIF4E →	+0.206	+3.598	.009	.001	3	1
UCEC	eIF4G →	+0.271	+2.321	.019	.034	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.700	.002	.001	3	1
UCEC	FASN →	+0.322	+1.807	.029	.025	3	1
UCEC	FoxM1 →	+0.243	+2.169	.012	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

c-Met_pY1235 by GAPT expression — UCEC

Explore this box plot interactively →