GAPDH

Across TCGA patient cohorts, GAPDH mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAPDH-associated genes across cancer lineages are VN1R91P, RNU6-479P, and RN7SKP257. Each is linked with GAPDH in more than 2 cancer types. Because this analysis shows association rather than direction, both GAPDH-to-partner and partner-to-GAPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R91P grouped by GAPDH-low versus GAPDH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAPDH→partner) and Y-score (partner→GAPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VN1R91P →	+0.198	+5.212	<.001	.002	3	3
SKCM	RNU6-479P →	+0.578	+3.875	<.001	.008	3	2
STAD	RN7SKP257 →	+0.309	+4.520	<.001	.005	3	2
BLCA	RNU6-1308P →	+0.878	+7.640	<.001	.009	3	2
BRCA	RN7SL673P →	+0.154	+8.055	<.001	.007	3	1
SKCM	MRPL49P2 →	+0.134	+3.838	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

VN1R91P by GAPDH expression — SKCM

Explore this box plot interactively →