GAPDH

Across TCGA pan-cancer cohorts, GAPDH RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of GAPDH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAPDH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAPDH is over-expressed in tumor.

KIRC, HNSC, and LUAD are the cancer types where GAPDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAPDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+2.226	<.001	12	view →
HNSC	Male	II,III,IV	+0.840	<.001	12	view →
LUAD	Female	II,III,IV	+1.793	<.001	11	view →
KIRP	Female	II,III,IV	+1.750	<.001	11	view →
COAD	Female	All	+1.130	<.001	11	view →
LUSC	Female	All	+2.565	<.001	9	view →
LIHC	Female	II,III,IV	+1.659	<.001	9	view →
BLCA	Male	All	+0.905	<.001	7	view →
THCA	Female	II,III,IV	+0.660	<.001	7	view →
UCEC	All	III,IV	+1.541	<.001	6	view →
BRCA	All	III,IV	+1.005	<.001	6	view →
CHOL	Female	All	+2.133	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

GAPDH–KIRC

Open the KIRC breakdown →