Across TCGA cell cohorts, GANC mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GANC-associated genes across cancer lineages are LYPD4, OR11H6, and WFDC10A. Each is linked with GANC in more than 1 cancer types. Because this analysis shows association rather than direction, both GANC-to-partner and partner-to-GANC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GANC→partner) and Y-score (partner→GANC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LYPD4 →	+0.072	+4.371	<.001	.005	3	2
CNS	OR11H6 →	+0.018	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.166	+4.315	<.001	.006	3	1
CNS	CYP2A13 →	+0.032	+5.044	<.001	.001	3	1
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

GANC survival (RNA) · tumor vs normal (RNA) · all GANC data types