GAMT

Across TCGA cell cohorts, GAMT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,615 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GAMT-associated GO terms across cancer lineages are Creatine metabolic process, Positive regulation of intracellular estrogen receptor signaling pathway, and Intracellular sodium ion homeostasis. Each is linked with GAMT in more than 11 cancer types. Because this analysis shows association rather than direction, both GAMT-to-partner and partner-to-GAMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Creatine metabolic process grouped by GAMT-low versus GAMT-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAMT→partner) and Y-score (partner→GAMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Creatine metabolic process →	+1.020	+2.146	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.140	+1.443	.001	.004	3	11
STOMACH	Intracellular sodium ion homeostasis →	-0.418	-3.123	<.001	<.001	3	10
OESOPHAGUS	Regulation of potassium ion transport →	-0.121	-2.212	.005	<.001	3	10
BONE	Base-excision repair →	+0.073	+0.980	<.001	<.001	3	10
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.123	+3.363	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,615 associations by consensus.

Creatine metabolic process by GAMT expression — LUNG_SCLC

Explore this box plot interactively →