GALNT8

Across TCGA patient cohorts, GALNT8 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALNT8-associated genes across cancer lineages are INPP4B, PDK1_pS241, and ACC1. Each is linked with GALNT8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GALNT8-to-partner and partner-to-GALNT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GALNT8-low versus GALNT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALNT8→partner) and Y-score (partner→GALNT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.371	-2.844	<.001	<.001	3	3
SKCM	PDK1_pS241 →	-0.132	-1.423	.020	.023	3	3
UCEC	ACC1 →	+0.284	+2.713	.011	.003	3	3
UCEC	TFRC →	+0.557	+3.700	<.001	.001	3	3
UCEC	ASNS →	+0.335	+1.584	.002	.032	3	3
UCEC	Cyclin-E2 →	+0.110	+1.201	.035	.028	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

INPP4B by GALNT8 expression — UCEC

Explore this box plot interactively →