GALNT8

Across TCGA pan-cancer cohorts, GALNT8 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GALNT8’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where GALNT8 RNA is repressed in tumor relative to normal tissue. In most cancer types GALNT8 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

BRCA, UCEC, and THCA are the cancer types where GALNT8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GALNT8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.636	<.001	6	view →
UCEC	All	II,III,IV	−0.562	<.001	6	view →
THCA	Female	All	−0.093	<.001	6	view →
KIRP	All	All	−0.063	<.001	5	view →
KICH	Male	All	−0.099	<.001	4	view →
COAD	Female	All	−0.836	.004	3	view →
LUSC	All	All	+0.337	.006	2	view →
BLCA	Male	IV	−0.205	.024	1	view →
LUSC	Male	III,IV	−0.110	<.001	1	view →
LUAD	Male	All	−0.065	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

GALNT8–BRCA

Open the BRCA breakdown →