GALK1

Across TCGA patient cohorts, GALK1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALK1-associated genes across cancer lineages are Ku80, Lck, and ATM. Each is linked with GALK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GALK1-to-partner and partner-to-GALK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GALK1-low versus GALK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALK1→partner) and Y-score (partner→GALK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.384	+3.013	.004	.019	3	1
UCEC	Lck →	+0.389	+3.000	<.001	.037	3	1
UCEC	ATM →	-0.639	-3.000	.014	.037	3	1
UCEC	ERK2 →	+0.260	+3.000	.019	.037	2	1
UCEC	eEF2 →	+0.526	+3.000	.010	.037	1	1
UCEC	PCNA →	+0.376	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by GALK1 expression — UCEC

Explore this box plot interactively →