GALK1

Across TCGA cell cohorts, GALK1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GALK1-associated genes across cancer lineages are CDH20, LMNTD1, and CDC20B. Each is linked with GALK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GALK1-to-partner and partner-to-GALK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by GALK1-low versus GALK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALK1→partner) and Y-score (partner→GALK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.110	+3.029	<.001	.003	3	1
LARGE_INTESTINE	LMNTD1 →	+0.208	+3.232	<.001	.001	3	1
LARGE_INTESTINE	CDC20B →	+0.070	+3.584	<.001	.003	3	1
LARGE_INTESTINE	S100G →	+1.020	+2.688	<.001	.008	3	1
LARGE_INTESTINE	KCND3 →	+0.280	+3.548	.009	.004	3	1
LARGE_INTESTINE	PROP1 →	+0.021	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CDH20 by GALK1 expression — LARGE_INTESTINE

Explore this box plot interactively →