GALC

Across TCGA patient cohorts, GALC mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALC-associated genes across cancer lineages are Notch1, ASNS, and EGFR_pY1068. Each is linked with GALC in more than 1 cancer types. Because this analysis shows association rather than direction, both GALC-to-partner and partner-to-GALC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GALC-low versus GALC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALC→partner) and Y-score (partner→GALC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+1.594	.002	.042	3	2
UCEC	ASNS →	+0.466	+1.662	<.001	.011	3	2
UCEC	EGFR_pY1068 →	-0.312	-2.392	<.001	<.001	3	1
UCEC	EGFR →	-0.169	-1.662	.002	.011	3	1
UCEC	A-Raf_pS299 →	-0.110	-2.222	.008	.010	3	1
UCEC	ERK2 →	+0.186	+1.362	.006	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by GALC expression — UCEC

Explore this box plot interactively →